Castleman disease is another rare disease that belongs to categories of rare cancers/viral infections/blood diseases. The other term for this condition is called multicentric Castleman disease. It affects the lymph nodes and other related tissues. It is a systemic condition that can affect lymph nodes and other tissues of multiple sets throughout the body. The other type is called unicentric Castleman disease that only has localized effects on the body. Oftentimes, MCD’s signs and symptoms are nonspecific and can only be due to the other more common conditions seen on the body of the patient. Symptoms do vary but usually, it includes weight loss, fever fatigue, enlarged lymph nodes, night sweats, enlarged spleen or liver and nausea & vomiting. Its exact underlying cause remains to be unknown. Its treatment may include the use of corticosteroid, undergoing chemotherapy or immunotherapy and or the use of anti-viral drugs.




Usually, the signs and symptoms of this disease are nonspecific. Once suspected, some tests need to be conducted in order to help in establishing its diagnosis and to known the other conditions that cause similar symptoms. Some of the tests are:


– Imaging studies (PET Scan, CT scan, MRI, ultrasound) can help in enlarged lymph nodes and other health problems identification.


– Blood testings for evaluation of Interleukin level and other body substance.


– Biopsy of the lymph nodes (often affected tissue) to confirm the diagnosis.




Treatment for this condition may vary depending on its severity and if the patient has or not have an autoimmune disease like HIV and/or type 8 of herpes virus. Some of the treatment options are:


– Chemotherapy. This can be recommended for those with slow-growing lymphatic cells.


– Immunotherapy. This can be used for blocking the interleukin action. This protein is excessively produced by those with MCD.


– Corticosteroid treatments for inflammation reduction.


– Anti-viral medicines which can help in blocking HHV-8 or HIV activities for those infected with such viruses.


Other details can be found here.

  1. July 12, 2018

    By the expert’s opinion that with localized, or unicentric, Castleman disease, your blood test will most likely be normal. If you have multicentric Castleman disease (MCD), you’ll often have unusual results on one or more of these tests: Complete blood count (CBC). You have to discuss with an expert as soon as possible. Thank you so much and keep up the great work!

  2. July 22, 2018

    Unicentric Castleman disease (UCD) only affects a single group of lymph nodes, often in your chest or belly. It’s the most common type. You can usually be cured if you have surgery to remove the trouble spots.However, surgery to remove an enlarged spleen may be an option to help ease symptoms. Treatment generally involves medications and other therapies to control cell overgrowth.

  3. July 27, 2018

    Castleman disease (CD) represents a group of rare and poorly-understood hyperinflammatory disorders that occur in people of all ages, cause lymph nodes to go big, and can cause dysfunction of multiple organs. The multicentic subtype, MCD, is as deadly disease as cancer (incuding all cancers combined).

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