Ace inhibitors or angiotensin-converting enzyme inhibitors work by reducing the process of angiotensin that converts to an enzyme. In the bloodstream, ACE is converting angiotensin 1 to angiotensin 11. The latter is a potent chemical which can cause muscles in the blood vessels to narrow and contract the blood vessels. Blood vessels narrowing can increase the pressure in the blood vessels that can cause hypertension or high blood pressure.
Once the activity of ACE has been reduced, ACE inhibitors can minimize the angiotensin 11 formation that can result in dilation or widening of the blood vessels. If such instance happens, blood pressure will normalize. Once the blood pressure is lowered, the heart needs to pump. This can minimize the amount of work that the heart needs to do. The drug can likewise reduce blood pressure in the kidneys. It can slow the progress of kidney disease caused by hypertension or diabetes.
Common conditions that ACE inhibitors are recommended:
Aside from lowering blood pressure, it can also be prescribed to those with CHR or congestive heart failure, diabetes-related kidney damage and even for stroke prevention. These drugs are highly essential for use because they work effectively in preventing sudden death caused by heart failures, high blood pressure, and heart attacks. A study was even made to patients with such diseases and it showed that those who took ACE inhibitors lived longer than those who did not. This type of drug can even be combined with other drugs in order to quickly or better normalize blood pressure level.
Some of the side effects
– a headache
– low blood pressure or hypotension
– a cough
There might also be abnormal taste like salty or metallic, sexual dysfunction, and an increased level of blood potassium.
About 5 to 25% of patients taking this medicine may experience a non-productive & persistent cough that may take two weeks or more.
Learn more here